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L9170

Sigma-Aldrich

Lipodisq®

Styrene: Maleic Anhydride Copolymer 3:1, Pre-hydrolyzed, powder, from synthetic

Synonym(s):

Lipid nanoparticle, Liposomal delivery system

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

biological source

synthetic

Quality Level

Assay

98-100%

form

powder

mol wt

9500 Da

storage condition

(Keep container tightly closed in a dry and well-ventilated place
Keep in a dry place)

storage temp.

room temp

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General description

Research area: Cell Structure

Lipodisq® polymers contain styrene and maleic acid monomer units. This product is the pre-hydrolyzed form of the SMA polymer, with styrene and maleic acid monomers. These polymer-lipid complexes are mainly generated by detergent-free methods.

Functional pH range: 6.0 - 9.0

Application

Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. In general, Lipodisq polymers are potentially useful in mitigating the use of detergents for the solubilization of membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

Legal Information

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Indra D Sahu et al.
Biochemistry, 52(38), 6627-6632 (2013-08-30)
Pulsed EPR DEER structural studies of membrane proteins in a lipid bilayer have often been hindered by difficulties in extracting accurate distances when compared to those of globular proteins. In this study, we employed a combination of three recently developed
Detergent-Free Formation and Physicochemical Characterization of Nanosized Lipid-Polymer Complexes: Lipodisq
Orwick MC, et al.
Angewandte Chemie (International ed. in English), 51(19), 4653-4657 (2012)
Juan F Bada Juarez et al.
Chemistry and physics of lipids, 222, 51-58 (2019-05-19)
Lipodisq™ nanoparticles have been used to extract surface lipids from the cuticle of two strains (wild type, N2 and the bacteria-resistant strain, agmo-1) of the C. elegans nematode without loss of viability. The extracted lipids were characterized by thin layer
Juan Francisco Bada Juarez et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183152-183152 (2019-12-18)
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regulation and hypertension. Drugs targeting dopaminergic neurotransmission have been
Maria Lyngaas Torgersen et al.
Journal of biomedical nanotechnology, 16(4), 419-431 (2020-09-25)
Many promising pharmaceutically active compounds have low solubility in aqueous environments and their encapsulation into efficient drug delivery vehicles is crucial to increase their bioavailability. Lipodisq nanoparticles are approximately 10 nm in diameter and consist of a circular phospholipid bilayer

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