K2638
Kallikrein from human plasma
buffered aqueous solution, ≥5 units/mg protein
Synonym(s):
Kininogenase, Kininogenin
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
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form
buffered aqueous solution
Quality Level
specific activity
≥5 units/mg protein
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... KLK1(3816)
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General description
Kallikrein-related peptidases belong to the family of 15 highly conserved trypsin- or chymotrypsin-like serine proteases. Plasma kallikrein (PK) is a serine protease derived from plasma prekallikrein, a zymogen found at higher levels in blood circulation. The KLKB1 gene is located on the human chromosome at 4q35.2.
Application
Kallikrein from human plasma has been used:
- to culture human hepatocellular carcinoma cell line
- to study its effects on the cleavage of Neisserial heparin binding antigen (NHBA) from Neisseria meningitidis
- in peptidase inhibition assay
Biochem/physiol Actions
Plasma kallikrein (PK) is involved in the synthesis of bradykinin, maintaining the blood metabolite levels and hypertension. It also participates in the activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. PK controls proteolytic cascades in the cardiovascular system like the kallikrein-kinin system, renin-angiotensin system, fibrinolytic system, and the alternative complement pathway. It is involved in the cleavage of glucagon-like peptide-1 (GLP-1) and neuropeptide Y (NPY) which suggests that plasma kallikrein may affect metabolism and diabetes.
Unit Definition
One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.
Physical form
Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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