I1521

DES (1-6) IGF II

lyophilized powder, recombinant, expressed in E. coli, suitable for cell culture

• CAS Number: 141909-47-9
• MDL number: MFCD00285687
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• biological source: human
• recombinant: expressed in E. coli
• Assay: ≥95% (HPLC)
• form: lyophilized powder
• potency: ≤100 ng/mL ED₅₀
• mol wt: 6,765 Da
• packaging: pkg of 20 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• color: white
• UniProt accession no.: P01344
• storage temp.: 2-8°C
• Gene Information: human ... IGF2(3481)

Description

General description

DES (1-6) IGF-II is a 61 amino acid analog of human insulin-like growth factor II, lacking the first six N-terminal amimo acids. DES (1-6) IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs), which are known to inhibit the actions of IGF′s.

Application

Used for studies of IGF-II function in cell culture applications. Use in combination with IGF-I, insulin and other forms of IGF-II to study receptor functions and cell signaling.

Other Notes

Recombinant analog of insulin-like growth factor II.

Preparation Note

Prepared from 0.1 M acetic acid.

Synthesized recombinantly in E. coli using a patented fusion protein expression system, DES (1-6) IGF-II is then purified by liquid chromatography. DES (1-6) IGF-II has been developed as an inexpensive, high quality potent analog of IGF-II for use as a growth factor supplement in cell culture. DES (1-6) IGF-II is supplied as a powder, lyophilized from 0.1 M acetic acid. Molecular weight is 6,765 daltons.