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GW21037

Sigma-Aldrich

Anti-CXCL10 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Small inducible cytokine B10

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21037

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_001556.1

UniProt accession no.

P02778

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCL10(3627)

Immunogen

Immunogen Sequence: GI # 4504701, sequence 22-98
Recombinant small inducible cytokine B10

Application

Anti-CXCL10 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

C-X-C motif chemokine 10 (CXCL10) is a protein encoded by the CXCL10 gene in humans. It is a potent chemoattractant for antiviral T-cells and NK-cells and is poorly associated with chronic hepatitis C virus (HCV). CXCL10 axis inhibits antiviral innate and adaptive host immunity, thereby favouring establishment of viral persistence. CXCL10 gene promoter may be partially responsible for the severity of cerebral malaria CM outcomes in males. Study shows the correlation of CXCL10 with the immunopathogenesis of vitiligo, an autoimmune disorder.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The role of the Th1 chemokine CXCL10 in vitiligo.
Alessandro Antonelli et al.
Annals of translational medicine, 3(Suppl 1), S16-S16 (2015-06-06)
Nana Wilson et al.
PloS one, 8(12), e81329-e81329 (2013-12-19)
The risk factors for cerebral malaria (CM) and the wide variation in clinical manifestations of malaria are poorly understood. Recent studies indicate that interferon gamma inducible chemokine, CXCL10, is a strong predictor of both human and experimental cerebral malaria. Increased
Antonio Riva et al.
Hepatology (Baltimore, Md.), 60(2), 487-496 (2014-03-29)
The pathogenesis of hepatitis C virus (HCV) infection is strongly influenced by the nature of the host's antiviral immunity. Counterintuitively, elevated serum concentrations of C-X-C chemokine 10 (CXCL10), a potent chemoattractant for antiviral T-cells and NK-cells, are associated with poor

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