G7127

Guanosine 5′-diphosphate sodium salt

Type I, ≥96% (HPLC)

• Synonym(s): GDP
• Empirical Formula (Hill Notation): C₁₀H₁₅N₅O₁₁P₂
• CAS Number: 43139-22-6
• Molecular Weight: 443.20
• MDL number: MFCD00070121
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895291
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 300
• type: Type I
• Assay: ≥96% (HPLC)
• form: powder
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1
• InChI: 1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;
• InChI key: PVMPTWQLNDHIEV-UHFFFAOYSA-N

Description

Application

Guanosine 5′-diphosphate sodium salt has been used:

• in GTP-γ-35S functional assays
• in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding
• in the expression and purification of recombinant proteins

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves