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Key Documents

COO/COA

EMU058151

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting mouse Pcsk9

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

description

Quality Level

100

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

GACAGGACCAGTGGAGAAGCCACAGTAGCTGCTGCCATCTGCTGCCGGAGCCGGCCTTCAGCAAAGGCCTCCTGGGTTCAGTGACAGCCTCAGGCAGGGATGGTGCTTGAGGCTGGGTGCAGAGATATGCCTGCATGGCTCTCTTGTAGCCAAAGGTGGGGAGATTCTGCGTGGGAGAACTTGGTGTCTCACCCTGGGTACCCATTCCTGGTGTATGGAAGCACCTCCTTCACGGTCAGGGGGCCTGTGCTTGGCTTTCTGCCATCAGACATTAAGCTGTAGCTGGCTCTGGCCAGCTGCTCCAGTGTACCAGAACCTGAGGATGCTCGCTGCAAGGCCTCAGTTCTCAGGCCTTAGGGTGTATTTGTCTTTCAGGAAGATCATAATGGACAGAGATCCTTGGAGGTTCAAAGACCAAGTACCAGACTGGAAAATTGAGTCTGAAAGCCACAAGGACAGTCAACTCACAGCCAGCTCACATTGCAGACACCATTTTGGGCTCCCTGATTAAATGCAGATCAGTTCTGCACACCTCCAG

Ensembl | mouse accession no.

ENSMUSG00000044254

NCBI accession no.

NM_153565

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... PCSK9(100102) , Pcsk9(100102)

Related Categories

MISSION® esiRNA

General description

MISSION^® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging.

Dan Heo et al.

Nanotechnology, 26(33), 335101-335101 (2015-08-01)

The specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors

Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

Shirya Rashid et al.

Circulation, 130(5), 431-441 (2014-07-30)

Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also

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