00541

Ruthenium Red

for microscopy, 85.0-115.0% (calc. on dry basis, AT)

• Synonym(s): Ammoniated ruthenium oxychloride
• Linear Formula: [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
• CAS Number: 11103-72-3
• Molecular Weight: 786.35
• Colour Index Number: 77800
• MDL number: MFCD00011479
• UNSPSC Code: 12352200
• PubChem Substance ID: 329747091
• NACRES: NA.47

Properties

• grade: for microscopy
• Quality Level: 100
• Assay: 85.0-115.0% (calc. on dry basis, AT)
• form: powder
• impurities: ~5% water
• solubility: water: 10 mg/mL, clear to turbid
• εmax: ≥150 at 529-539 nm
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]
• InChI: 1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
• InChI key: ZXYSDUPLHOJIOR-UHFFFAOYSA-H

Description

General description

Ruthenium red is an inorganic cationic dye. It is also known as ammoniated ruthenium oxychloride. It is a large coordination complex consisting of three metal atoms connected by bridging oxygens, in addition to multiple amine ligands.

Application

Ruthenium red is suitable for use in light microscopy to stain pectins. It is also used to stain glycosaminoglycans by employing a two-color staining method with alcian blue. It serves as a typical basic dye at a higher pH that stains nuclei, Nissl substance, cartilage matrix, and mast cell granules. Other applications involving light microscopy include staining resin-embedded material. Ruthenium red is an important component of fixatives of the bacterial glycocalyx.

Inhibits mitochondrial Ca²⁺ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.

Biochem/physiol Actions

Ruthenium red inhibits mitochondrial Ca2+ uniporter. It is a known capsaicin antagonist. Additionally, it is known to block VR1 vanilloid receptor-coupled ion channels.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable