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MAB356

Sigma-Aldrich

Anti-Substance P Antibody, pain, clone NC1

culture supernatant, clone NC1, Chemicon®

Synonym(s):

Anti-Hs.2563, Anti-NK2, Anti-NKNA, Anti-NPK, Anti-TAC2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

culture supernatant

antibody product type

primary antibodies

clone

NC1, monoclonal

species reactivity

human

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgG2a

NCBI accession no.

NM_003182.1
NM_013996.1
NM_013997.1
NM_013998.1

UniProt accession no.

P20366

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TAC1(6863)

Specificity

Reacts with COOH-terminal end of Substance P. No cross-reactivity to Leu- or Met- enkephalin, somatostatin or beta-endorphin. Eledoisin 5%.

Immunogen

Substance P conjugated to BSA.

Application

1:100 - 1:200 by immunohistochemistry on human brain.

Optimal working dilutions must be determined by end user.
Detect Substance P using this Anti-Substance P Antibody, pain, clone NC1 validated for use in IH.

Physical form

Lyophilized Supernatant, preservative free.

Storage and Stability

Lyophilized antibody can be kept at 2-8°C for up to 3 months and should be kept at -20°C for long term storage. Reconstitute with 100μL sterile DI water. Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.
Ding, S; Chi, MM; Scull, BP; Rigby, R; Schwerbrock, NM; Magness, S; Jobin, C; Lund, PK
Testing null
Sacro-lumbar intersegmental spinal reflex in autonomic pathways mediating female sexual function.
Shi Yong Yuan,Ian L Gibbins,Vladimir P Zagorodnyuk,Judy L Morris
Journal of Sexual Medicine null
Ultrastructure and distribution of substance P-immunoreactive sensory collaterals in the guinea pig prevertebral sympathetic ganglia.
Matthews, M R, et al.
The Journal of Comparative Neurology, 258, 28-51 (1987)
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Zimmer, A; Zimmer, AM; Baffi, J; Usdin, T; Reynolds, K; Konig, M; Palkovits, M; Mezey, E
Proceedings of the National Academy of Sciences of the USA null
Andrew P Ray et al.
Pharmacology, biochemistry, and behavior, 94(1), 211-218 (2009-08-25)
Research on the mechanisms of emesis has implicated multiple neurotransmitters via both central (dorsal vagal complex) and peripheral (enteric neurons and enterochromaffin cells) anatomical substrates. Taking advantage of advances in receptor-specific agonists, and utilizing Fos expression as a functional activity
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