565750

γ-Secretase Inhibitor I

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(s): γ-Secretase Inhibitor I, Z-LLNle-CHO
• Empirical Formula (Hill Notation): C₂₆H₄₁N₃O₅
• Molecular Weight: 475.62
• UNSPSC Code: 12352200

Properties

• Quality Level: 200
• Assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: DMSO: 10 mg/mL; 50% acetic acid: soluble
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.

Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable