444295

MT1-MMP Inhibitor, NSC405020

The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): MT1-MMP Inhibitor, NSC405020, 3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide
• Empirical Formula (Hill Notation): C₁₂H₁₅Cl₂NO
• CAS Number: 7497-07-6
• Molecular Weight: 260.16
• MDL number: MFCD02006898
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: ClC1=C(Cl)C=C(C(NC(C)CCC)=O)C=C1

Description

General description

A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Other Notes

Remacle, A.G., et al. 2012. Cancer Res.72, 2339.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable