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Key Documents

O-030

Supelco

Oxymorphone-3-β-D-glucuronide solution

100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C23H27NO10
CAS Number:
Molecular Weight:
477.46
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

100 μg/mL in methanol: water (1:1)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

2-8°C

SMILES string

CN1CC[C@]23[C@H]4Oc5c(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)ccc(C[C@@H]1[C@]2(O)CCC4=O)c35

InChI

1S/C23H27NO10/c1-24-7-6-22-13-9-2-3-11(32-21-16(28)14(26)15(27)18(34-21)20(29)30)17(13)33-19(22)10(25)4-5-23(22,31)12(24)8-9/h2-3,12,14-16,18-19,21,26-28,31H,4-8H2,1H3,(H,29,30)/t12-,14+,15+,16-,18+,19+,21-,22+,23-/m1/s1

InChI key

ILRLBQVIWURYLX-WUDROUKASA-N

General description

A certified Snap-N-Spike® solution of Oxymorphone-3ß-D-glucuronide suitable for use in a variety of GC/MS or LC/MS applications such as pain prescription monitoring, clinical toxicology, pharmaceutical research, forensic analysis, or urine drug testing. Oxymorphone-3ß-D-glucuronide is a major metabolite of oxymorphone in urine and plasma. Oxymorphone, sold under trade names such as Opana®, Numorphan®, and Numorphone, is an opiate analgesic indicated for relief of moderate to severe pain.

Application


  • Validation of a thin-layer chromatography/densitometry method for the characterization of invertase activity.: This study validated a TLC-densitometric method using Silica gel 60 F₂₅₄ for the characterization of invertase activity, demonstrating the technique′s robustness and reliability in analyzing enzyme activity (Ferey et al., 2016).

  • Stability-Indicating TLC-Densitometric and HPLC Methods for the Simultaneous Determination of Piracetam and Vincamine in the Presence of Their Degradation Products.: This research developed and validated stability-indicating methods using TLC-densitometry with Silica gel 60 F₂₅₄ and HPLC for the simultaneous determination of piracetam and vincamine, highlighting the methods′ precision and sensitivity in the presence of degradation products (Ahmed et al., 2016).

  • TLC densitometric method for the preliminary evaluation of fucoxanthin-based products.: This paper presented a TLC-densitometric method utilizing Silica gel 60 F₂₅₄ for the analysis of fucoxanthin in commercial products, showing its effectiveness for preliminary quality assessment of these products (Piovan et al., 2014).

  • Modulation of the cardiac membrane-bound cyclic nucleotide phosphodiesterase: inhibition due to a contamination of TLC purified S-adenosyl-L-[methyl-3H] methionine by Zn++ ions.: This study investigated the inhibition of cardiac membrane-bound cyclic nucleotide phosphodiesterase by Zn++ ions, which were contaminants in TLC purified S-adenosyl-L-[methyl-3H] methionine using Silica gel 60 F₂₅₄, emphasizing the need for careful sample preparation in biochemical assays (Dubois et al., 1985).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Numorphan is a registered trademark of Endo Pharmaceuticals Inc.
Opana is a registered trademark of Endo Pharmaceuticals Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

75.2 °F - closed cup

Flash Point(C)

24 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protocols

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

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