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850395C

Avanti

18:3 (Cis) PC

Avanti Research™ - A Croda Brand 850395C

Synonym(s):

1,2-dilinolenoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C44H76NO8P
CAS Number:
2701-19-1
Molecular Weight:
778.05
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850395C-25mg)
pkg of 2 × 4 mL (850395C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850395C

concentration

10 mg/mL (850395C-25mg)
25 mg/mL (850395C-200mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

General description

18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine is an unsaturated glycerophospholipid, with substitution of two chains of linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, along with choline as a headgroup.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine:
  • might be used in aqueous lipid-trehalose formulations to assess the long-term storage stability of lyophilized liposomes
  • might be used in phospholipid monolayer to study the instability of unsaturated phospholipids at specified conditions
  • has been used in aqueous sugar formulations or liposome formulations to characterize its degradation during lyophilization

Packaging

5 mL Clear Glass Sealed Ampule (850395C-200mg)
5 mL Clear Glass Sealed Ampule (850395C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Description
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Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N M Payton et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 85(2), 306-313 (2013-04-10)
As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g., lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during lyophilization and/or during prolonged storage. The goal of the current

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