SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• Synonym(s): 5′- nucleotidase, Ecto-5′-nucleotidase
• UNSPSC Code: 12352202
• NACRES: NA.26

Properties

• recombinant: expressed in HEK 293 cells
• form: frozen liquid
• mol wt: 58.6 kDa
• UniProt accession no.: P21589
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... NT5E(4907)

Description

General description

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

Application

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

Biochem/physiol Actions

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

Physical form

Aqueous solution

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable