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SML1274

Sigma-Aldrich

RI-1

≥98% (HPLC)

Synonym(s):

3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

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About This Item

Empirical Formula (Hill Notation):
C14H11Cl3N2O3
CAS Number:
415713-60-9
Molecular Weight:
361.61
MDL number:
MFCD00814248
UNSPSC Code:
12352200
PubChem Substance ID:
329825761
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)C=CC(N2C(C(N3CCOCC3)=C(Cl)C2=O)=O)=C1

InChI

1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2

InChI key

MWSUIZKGNWELRF-UHFFFAOYSA-N

Biochem/physiol Actions

RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
045M4705V

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Todd W Lewis et al.
Nucleic acids research, 47(7), 3503-3520 (2019-02-05)
The primary function of the UBE2T ubiquitin conjugase is in the monoubiquitination of the FANCI-FANCD2 heterodimer, a central step in the Fanconi anemia (FA) pathway. Genetic inactivation of UBE2T is responsible for the phenotypes of FANCT patients; however, a FANCT

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