SML0066

NGB 2904 hydrochloride

≥98% (HPLC)

• Synonym(s): N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
• Empirical Formula (Hill Notation): C₂₈H₂₉Cl₂N₃O·HCl
• CAS Number: 189061-11-8
• Molecular Weight: 530.92
• MDL number: MFCD09971107
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825130
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥25 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
• InChI: 1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
• InChI key: PFIWYJNBKGCVFM-UHFFFAOYSA-N

Description

Application

NGB 2904 hydrochloride may be used in cell signaling studies.

Biochem/physiol Actions

Inhibition of dopamine D₃ receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.

NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable