Skip to Content
Merck
All Photos(1)

Key Documents

SCP0200

Sigma-Aldrich

Neuromedin N

Synonym(s):

NMN-125, NN, NT/N, NmN

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C38H63N7O8
Molecular Weight:
745.95
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

UniProt accession no.

P30990

storage temp.

−20°C

Gene Information

human ... NTS(4922)

Amino Acid Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Biochem/physiol Actions

Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

I Schultz et al.
Regulatory peptides, 35(3), 197-205 (1991-09-03)
The effects of neuromedin-N on migrating myoelectric complexes in the small intestine of rats were studied. As neuromedin-N and neurotensin are structurally related peptides a comparison with neurotensin was made. Myoelectric activity was recorded by means of three bipolar electrodes
Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model.
Wakabayashi-Nakao K
Oncology Reports, 28(4), 1181-1186 (2012)
M De la Fuente et al.
Journal of neuroimmunology, 42(1), 97-104 (1993-01-01)
The neuropeptides neurotensin and neuromedin N (from 10(-12) M to 10(-9) M) have been shown in this study to stimulate significantly in vitro several steps of the phagocytic process: adherence to substrate, chemotaxis, ingestion of inert particles (latex beads) and
E B Binder et al.
Pharmacological reviews, 53(4), 453-486 (2001-12-06)
Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential
J J Garrido et al.
Regulatory peptides, 41(1), 27-37 (1992-09-03)
The action of neurotensin and related peptides has not been yet studied on lymphocytes, although there are studies indicating the stimulative action of neurotensin, a peptide first isolated from bovine hypothalamus, on different functions of phagocytic immune cells. The present
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service