SAB4702032

Monoclonal Anti-CD120a purified low endotoxin produced in mouse

• Synonym(s): FPF, TBP1, TNF R1, TNFR55, TNFRSF1A, p60
• UNSPSC Code: 12352203

Properties

• conjugate: unconjugated
• Quality Level: 100
• antibody product type: primary antibodies
• clone: H398, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: 1 mg/ml
• technique(s): FUNC: suitable; flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• isotype: IgG2a
• UniProt accession no.: P19438
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... TNFRSF1A(7132)

Description

General description

CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Specificity

The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

Immunogen

Recombinant full length human CD120a

Physical form

Phosphate buffered saline (PBS), pH 7.4

Preparation Note

Purified by protein-A affinity chromatography.

Storage and Stability

Store at 2-8°C. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1