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S6768

Sigma-Aldrich

N-Succinyl-Phe-Gly-Leu-β-naphthylamide

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About This Item

Empirical Formula (Hill Notation):
C31H36N4O6
CAS Number:
117756-24-8
Molecular Weight:
560.64
MDL number:
MFCD00070360
UNSPSC Code:
12352204
PubChem Substance ID:
24899721
NACRES:
NA.83

form

solid

Quality Level

200

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)CNC(=O)C(Cc1ccccc1)N2C(=O)CCC2=O)C(=O)Nc3ccc4ccccc4c3

InChI

1S/C31H34N4O5/c1-20(2)16-25(30(39)33-24-13-12-22-10-6-7-11-23(22)18-24)34-27(36)19-32-31(40)26(17-21-8-4-3-5-9-21)35-28(37)14-15-29(35)38/h3-13,18,20,25-26H,14-17,19H2,1-2H3,(H,32,40)(H,33,39)(H,34,36)

InChI key

SGVJLMFFXDTAFJ-UHFFFAOYSA-N

Substrates

Substrate for an LHRH-degrading neutral endopeptidase

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
067F0720

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B Horsthemke et al.
Biochemistry, 19(13), 2867-2873 (1980-06-24)
A neutral endopeptidase which degrades luteinizing hormone-releasing hormone (LH-RH, <GLu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GLy-NH2) has been purified 900-fold from extracts of bovine anterior pituitary. This Ca2+-independent enzyme of 83 000 molecular weight (as estimated by gel filtration) cleaves LH-RH (KM = 180 microM) at

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