C1108
Anti-Cannabinoid Receptor 1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-CANN6, Anti-CB-R, Anti-CB1, Anti-CB1A, Anti-CB1K5, Anti-CB1R, Anti-CNR
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen ~52 kDa
species reactivity
rat, human
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CNR1(1268)
rat ... Cnr1(25248)
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Immunogen
fusion protein containing amino acids 1-99 of the human CB1 receptor.
Application
Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:250 and for immunocytochemistry at a working dilution of 1:1000.
Biochem/physiol Actions
Cannabinoids exert their well-known physiological effects through two G-protein coupled receptors, CB1 and CB2. The cannabinoid receptor type 1 (CB1) is widely distributed in mammalian tissues, with the highest concentrations found in brain neurons while CB2 receptor function primarily in the peripheral immune system, found in spleen and may be present in the central nervous system, including the retina. The cannabinoid receptor type 1 are involved in modulation of adenylate cyclase and ion channels. It is also involved in the modulation of nociception, movement, learning and memory, emotion and many other neuronal processes. It also plays an essential role in drug addiction. CB1 receptor blockade may be useful for treatment of angiotensin II-dependent hypertension and associated metabolic syndrome.
Physical form
Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin, 50% glycerol, and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Natasha L Grimsey et al.
Journal of neuroscience methods, 171(1), 78-86 (2008-04-15)
The study of endogenous cannabinoid CB1 receptor proteins in neuronal tissues and cells relies on the availability of highly specific antibodies. We have tested the ability of a series of CB1 antibodies to detect endogenous receptors in brain as well
Laura Orio et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(15), 4846-4857 (2009-04-17)
Extended access to cocaine produces an increase in cocaine self-administration in rats that mimics aspects of compulsive drug intake in human addicts. Although emerging evidence implicates the endogenous cannabinoid system in aspects of opioid and ethanol addiction, a role of
R G Pertwee
Current medicinal chemistry, 6(8), 635-664 (1999-09-02)
Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB2 receptors occur in certain non-neuronal tissues
Hajar Miranzadeh Mahabadi et al.
Molecular brain, 14(1), 89-89 (2021-06-09)
The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons throughout the central nervous
C C Felder et al.
Annual review of pharmacology and toxicology, 38, 179-200 (1998-05-23)
Marijuana has been in use for over 4000 years as a therapeutic and as a recreational drug. Within the past decade, two cannabinoid receptor types have been identified, their signal transduction characterized, and an endogenous lipid agonist isolated from mammalian
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