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B1434

Sigma-Aldrich

Bone Morphogenetic Protein 7 human

>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Synonym(s):

BMP-7, OP-1, Osteogenic protein 1

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About This Item

MDL number:
MFCD03702812
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in CHO cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.2-0.6 μg/mL ED50

mol wt

monomer calculated mol wt 15.7 kDa
 18-20 kDa by SDS-PAGE (reducing)
 30-40 kDa by SDS-PAGE (non-reducing)

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P18075

storage temp.

−20°C

Gene Information

human ... BMP7(655)

Related Categories

Biochem/physiol Actions

Cellular responses to BMP-7 are mediated by the formation of hetero-oligomeric complexes of type I and II serine/threonine kinase receptors. Human and mouse BMP-7 share 98% amino acid sequence identity.

Physical form

Lyophilized from 50.0 μl of a 0.2 μm filtered solution in 35% acetonitrile, 0.1% TFA containing 50 μg bovine serum albumin per 1μg of cytokine.

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production using mouse ATDC-5 chondrogenic cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A J Celeste et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(24), 9843-9847 (1990-12-01)
Characterization of the polypeptides present in bone-inductive protein extracts from bovine bone has led to the cloning of seven regulatory molecules, six of which are distantly related to transforming growth factor beta. The three human bone morphogenetic proteins (BMPs) we
A H Reddi
Nature biotechnology, 16(3), 247-252 (1998-04-07)
Morphogenesis is the developmental cascade of pattern formation and body plan establishment, culminating in the adult form. It has formed the basis for the emerging discipline of tissue engineering, which uses principles of molecular developmental biology and morphogenesis gleaned through
Yan Wang et al.
Experimental and molecular pathology, 98(3), 393-402 (2015-03-17)
This study presented the effect of bone morphogenic protein-7 (BMP-7) inhibiting epithelial-mesenchymal transition (EMT) in silicosis model. In vivo, Wistar rats were exposed to silica by intratracheal instillation. Seven days later rats were treated with BMP-7. Rats were sacrificed at
Endre Kristóf et al.
Scientific reports, 5, 12540-12540 (2015-07-28)
Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations with gene expression pattern
Pilar González-Gómez et al.
Oncotarget, 6(13), 10950-10963 (2015-04-11)
Glioblastoma tumor initiating cells are believed to be the main drivers behind tumor recurrence, and therefore therapies that specifically manage this population are of great medical interest. In a previous work, we synthesized controlled release microspheres optimized for intracranial delivery
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