18503

Methyl trifluoromethanesulfonate

for GC derivatization, LiChropur^™, 98.0%

• Synonym(s): Methyl triflate
• Linear Formula: CF₃SO₂OCH₃
• CAS Number: 333-27-7
• Molecular Weight: 164.10
• Beilstein: 774772
• EC Number: 206-371-7
• MDL number: MFCD00000409
• UNSPSC Code: 41116105
• PubChem Substance ID: 329751681
• NACRES: NA.22

Properties

• grade: for GC derivatization
• Quality Level: 100
• Assay: ≥98.0% (GC); 98.0%
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Acylations
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.326 (lit.); n20/D 1.327
• bp: 94-99 °C (lit.)
• density: 1.45 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: COS(=O)(=O)C(F)(F)F
• InChI: 1S/C2H3F3O3S/c1-8-9(6,7)2(3,4)5/h1H3
• InChI key: OIRDBPQYVWXNSJ-UHFFFAOYSA-N

Description

General description

Methyl trifluoromethanesulfonate (Methyl triflate) is a strong methylating agent. It is also a powerful alkylating agent and a strong irritant.

Shown to be the most effective monomethylating agent in reactions with potassium enolates.
Useful methylation reagent for the conversion of amines to methyl ammonium triflates.

Application

Methyl trifluoromethanesulfonate was used in the synthesis of 2-Benzyloxy-1-methylpyridinium trifluoromethanesulfonate.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H301 + H311,H314,H330
• Precautionary Statements: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 100.4 °F - closed cup
• Flash Point(C): 38 °C - closed cup