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14131

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Iopanoic acid

analytical standard

Synonym(s):

2-(3-Amino-2,4,6-triiodobenzyl)butyric acid, 3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropanoic acid, Iodopanoic acid

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About This Item

Empirical Formula (Hill Notation):
C11H12I3NO2
CAS Number:
96-83-3
Molecular Weight:
570.93
EC Number:
202-539-9
MDL number:
MFCD00038687
UNSPSC Code:
41116107
PubChem Substance ID:
329750405
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

150-156 °C

application(s)

clinical

format

neat

storage temp.

2-8°C

SMILES string

O=C(O)C(CC)CC1=C(I)C(N)=C(I)C=C1I

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General description

Iopanoic acid is an oral cholecystographic agent, which is rich in iodine and is a potent inhibitor of 5′-deiodinase.[1]
This radiographic contrast agent prevents the release of thyroid hormone from the thyroid gland. It also inhibits the conversion of thyroxine to triiodothyronine.[2]

Application

Iopanoic acid may be used as a standard to investigate the presence and regulation of type 3 iodothyronine deiodinase in human cardiomyocytes.[3]

Recommended products

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCC6613
    BCBV8566

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    3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder

    Sigma-Aldrich

    T2877

    3,3′,5-Triiodo-L-thyronine

    Iopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomy.
    Bogazzi F, et al.
    Journal of Endocrinological Investigation, 25(2), 176-180 (2002)
    Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).
    Obregon JM, et al.
    Endocrinology, 106(6), 1827-1836 (1980)
    Type 3 iodothyronine deiodinase is expressed in human induced pluripotent stem cell derived cardiomyocytes.
    Nishimura K, et al.
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