03641

Dansyl chloride

for HPLC derivatization, LiChropur^™, ≥99.0% (HPLC)

• Synonym(s): 5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl
• Empirical Formula (Hill Notation): C₁₂H₁₂ClNO₂S
• CAS Number: 605-65-2
• Molecular Weight: 269.75
• Beilstein: 2217205
• EC Number: 210-092-6
• MDL number: MFCD00003985
• UNSPSC Code: 41116105
• PubChem Substance ID: 329747747
• NACRES: NA.22

Properties

• grade: for HPLC derivatization
• Quality Level: 100
• Assay: ≥99.0% (HPLC)
• form: powder or crystals
• quality: LiChropur^™
• technique(s): HPLC: suitable
• mp: 72-74 °C (lit.)
• solubility: acetone: 0.2 g/10 mL, clear to slightly turbid, yellow to very dark yellow-orange
• storage temp.: 2-8°C
• SMILES string: CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
• InChI: 1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
• InChI key: XPDXVDYUQZHFPV-UHFFFAOYSA-N

Description

General description

Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.

Application

Dansyl chloride has been used for the fluorogenic labeling of xenoestrogens, 4-nonylphenol and bisphenol A prior to their determination by high-performance liquid chromatography (HPLC) with fluorescence detection. It has also been used for the derivatization of icariin in human serum samples after oral administration of Epimedium decoction, followed by its determination using ultrasensitive LC-tandem mass spectrometry (LC-MS) and for the derivatization of antitumoral agent ES-285 in dog plasma followed by its analysis by HPLC equipped with ultraviolet and fluorescence detection.

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H290,H314
• Precautionary Statements: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3