8.51013
HATU
for peptide synthesis, Novabiochem®
Synonym(s):
HATU, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
About This Item
Recommended Products
product name
HATU, Novabiochem®
Quality Level
product line
Novabiochem®
form
solid
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
186 °C (decomposes)
application(s)
peptide synthesis
storage temp.
2-8°C
InChI
1S/C10H15N6O/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9/h5-7H,1-4H3/q+1
InChI key
WXIONIWNXBAHRU-UHFFFAOYSA-N
General description
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
[2] F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
[3] J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.
Linkage
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Identity (NMR, 1H): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
4.1A - Other explosive hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Articles
Novabiochem® offers a large number of coupling reagents for in situ activation. In situ activating reagents are easy to use, fast reacting – even with sterically hindered amino acids, and their use is generally free of side reactions
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