203701
bpV(HOpic)
A potent phosphotyrosine phosphatase inhibitor.
Synonym(s):
bpV(HOpic), Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
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About This Item
Linear Formula:
K2[VO(O2)2C6H4NO3] · 4H2O
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥70% (51V-NMR)
form
solid
potency
14 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
water: 4 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
PTEN
PTEN
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Unstable in solution; reconstitute just prior to use.
Other Notes
Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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