14-574-M

EphA4 Protein, active, 250 µg

• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Properties

• recombinant: expressed in baculovirus infected Sf21 cells
• Quality Level: 300
• description: protein target EphA4
• purified by: (Ni²⁺/NTA-agarose)
• technique(s): activity assay: suitable
• UniProt accession no.: P54764
• Gene Information: human ... EPHA4(2043)

Description

General description

FUNCTION: SwissProt: P54764 # Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.
SIZE: 986 amino acids; 109860 Da
SUBUNIT: Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Ubiquitous.
DOMAIN: SwissProt: P54764 The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.

Packaging

Also available in 10 μg size (cat#14-574) and in bulk (cat# 14-574-K).

Quality

Routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)

Physical properties

37kDa

Storage and Stability

6 months at -70°C

Analysis Note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.