05-22-3838

BQ-788, Sodium Salt

• Synonym(s): BQ-788, Sodium Salt, N- cis-2,6-Dimethylpiperidinocarbonyl-L-γ-MeLeu-D-Trp(MeOCO)-D-Nle-OH, Na
• Empirical Formula (Hill Notation): C₃₄H₅₀N₅NaO₇
• Molecular Weight: 663.78
• UNSPSC Code: 12352200
• NACRES: NA.28

Properties

• Assay: ≥95% (HPLC)
• Quality Level: 100
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: white to off-white
• solubility: 0.01% NH₄OH: 1 mg/mL; DMSO: 2 mg/mL; methanol: water (3:1): 2 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A highly selective and competitive ETB receptor antagonist (IC₅₀ = 1.2 nM).

Highly selective ET_B-receptor antagonist (IC₅₀ = 1.2 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
ETB-receptor antagonist

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.2 nM as ETB-receptor antagonist

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO and Methano:H₂O stock solutions are stable for up to 2 months at -20°C.

Other Notes

Okada, M., and Nishikibe, M. 2002. Cardiovasc. Drug Reviews20, 53.
Taniai, H., et al. 2001. Hepatology33, 894.
Fukuroda, T., et al. 1994. Biochem. Biophys. Res. Commun.199, 1461.
Ishikawa, K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 4892.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable