933910
Linear polyethylenimine-block-poly(ethylene glycol)
PEG average Mn 5,000, PEI average Mn 30,000
Synonym(s):
PEG-b-PEI, Poly(ethylene glycol)-block-polyethylenimine
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About This Item
Linear Formula:
CH3(C2H4O)n(C2H5N)mOH
UNSPSC Code:
12352207
NACRES:
NA.21
Recommended Products
form
powder or solid
Quality Level
mol wt
PEG 5,000 Da
PEG average Mn 5,000
PEI 30,000 Da
PEI average Mn 30,000
color
white to pale yellow
storage temp.
2-8°C
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Application
Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy.
Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.
Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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