927600
BrBT-alkyne
≥95%
Synonym(s):
2-Bromo-N-(prop-2-yn-1-yl)benzo[d]thiazole-6-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C11H7BrN2OS
CAS Number:
Molecular Weight:
295.16
UNSPSC Code:
12352101
NACRES:
NA.22
Application
BrBT-alkyne is a probe that can be used to lable cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitave applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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