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671592

Sigma-Aldrich

O-(2-Aminoethyl)-O′-(2-carboxyethyl)polyethylene glycol 5,000 hydrochloride

Mp 5,000

Synonym(s):

Polyethylene glycol

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About This Item

Linear Formula:
NH2CH2CH2O(CH2CH2O)nCH2CH2COOH . HCl
CAS Number:
187848-66-4
UNSPSC Code:
51171641
NACRES:
NA.22

mol wt

Mp 5,000

reaction suitability

reagent type: cross-linking reagent

Ω-end

carboxylic acid

α-end

amine

Application

Used for:
  • Aggregation to vesicle polymersomes and immobilization of functionalized peroxidase of permethylated ß-cyclodextrin-appended polystyrene giant amphiphile
  • Platform for oligonucleotide delivery utilizing PEG prodrug approach
  • Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

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