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1029002

USP

Amitriptyline hydrochloride

Name: Amitriptyline hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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About This Item

Formule empirique (notation de Hill):

C₂₀H₂₃N · HCl

Numéro CAS:

549-18-8

Poids moléculaire :

313.86

Numéro MDL:

MFCD00012537

Code UNSPSC :

41116107

ID de substance PubChem :

329749005

Nomenclature NACRES :

NA.24

Qualité

pharmaceutical primary standard

Famille d'API

amitriptyline

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

Clé InChI

KFYRPLNVJVHZGT-UHFFFAOYSA-N

Informations sur le gène

human ... SLC6A2(6530) , SLC6A4(6532)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amitriptyline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Amitriptyline Hydrochloride Tablets
Chlordiazepoxide and Amitriptyline Hydrochloride Tablets
Cyclobenzaprine Hydrochloride Extended-Release Capsules
Perphenazine and Amitriptyline Hydrochloride Tablets

Actions biochimiques/physiologiques

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

Mention d'avertissement

Danger

Mentions de danger

H301,H319,H361d,H410

Conseils de prudence

P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338

Classification des risques

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline.

Ming Yang et al.

Aquatic toxicology (Amsterdam, Netherlands), 151, 68-76 (2014-01-23)

Amitriptyline is a tricyclic antidepressant used for decades. It is present at low detectable concentrations in the aquatic environment, but relative few studies have focused on its ecotoxicological effects on non-target aquatic animals. The present study conducted an acute toxicity

Chronic idiopathic nausea of childhood.

Katja Kovacic et al.

The Journal of pediatrics, 164(5), 1104-1109 (2014-03-13)

To compare children with primary, chronic idiopathic nausea to those with secondary nausea associated with functional abdominal pain. Retrospective chart review of 45 children with a primary complaint of chronic nausea several times per week. Comparisons were made to prospectively

Influence of combined therapy with rosuvastatin and amitriptyline on the oxidation-reduction status in rats.

Mariola Herbet et al.

Acta poloniae pharmaceutica, 70(5), 913-917 (2013-10-24)

The aim of the present study was to assess the impact of combined therapy with rosuvastatin (10 mg/kg) and amitriptyline (10 mg/kg) on oxidation-reduction status in the blood of rats. After 2-week application of drugs alone or their combination, the

A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors.

Jennifer S Gewandter et al.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(7), 1807-1814 (2014-02-18)

Chemotherapy-induced peripheral neuropathy (CIPN) occurs in as high as 70% of patients receiving certain types of chemotherapy agents. The FDA has yet to approve a therapy for CIPN. The aim of this multicenter, phase III, randomized, double-blind, placebo-controlled trial was

Treatment of epidermolysis bullosa pruriginosa using systemic and topical agents.

Aaron R Mangold et al.

Journal of the American Academy of Dermatology, 70(6), e136-e137 (2014-05-17)

Afficher tous les articles scientifiques apparentés

Articles

HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide

-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder; Norclomipramine hydrochloride, ~99% (TLC), powder; Imipramine hydrochloride solution, drug standard, 1.0 mg/mL in methanol; Amitriptyline hydrochloride, ≥98% (TLC), powder; Clomipramine hydrochloride, ≥98% (HPLC), powder

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