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Key Documents

1000420

USP

Abacavir Related Compound A

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

(1S,4R)-4-[2,6-Diamino-9H-purin-9-yl]-2-cyclopentene-1-methanol

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About This Item

Formule empirique (notation de Hill):
C11H14N6O
Numéro CAS:
124752-25-6
Poids moléculaire :
246.27
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

abacavir

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

InChI

1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

Clé InChI

ZKJUXHDSLJYKED-RQJHMYQMSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Abacavir Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1000485

Abacavir Related Compounds Mixture, United States Pharmacopeia (USP) Reference Standard

1000496

Abacavir Stereoisomers Mixture, United States Pharmacopeia (USP) Reference Standard

1000500

Abacavir System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

1000408

Abacavir sulfate, United States Pharmacopeia (USP) Reference Standard

1000419

Abacavir sulfate racemic, United States Pharmacopeia (USP) Reference Standard

1000452

Abacavir Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1256

Abacavir sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001561

Abacavir sulfate, European Pharmacopoeia (EP) Reference Standard

Y0001551

Abacavir for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001552

Abacavir for peak identification, European Pharmacopoeia (EP) Reference Standard

1000437

Abacavir Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP1112

Abacavir sulfate, British Pharmacopoeia (BP) Reference Standard

BP1113

Abacavir impurity standard, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H318

Conseils de prudence

P280 - P305 + P351 + P338

Classification des risques

Eye Dam. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 28(6), 672-679 (2000-05-23)
A CBV [(-)-carbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxyguanosine] prodrug, 6AC [(-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine], was previously evaluated in rats, and it exhibited superiority to the parent drug in increasing systemic and central nervous system exposure to CBV. The gut wall was determined
R L Yeager et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(2), 462-466 (1991-03-01)
The potential for the metabolic conversion of (-)-6-aminocarbovir to (-)-carbovir, a potent reverse transcriptase inhibitor effective against human immunodeficiency virus, has been examined in male Sprague-Dawley rats. Plasma (-)-6-aminocarbovir concentrations declined rapidly in a biphasic manner following an iv bolus
Y Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 27(1), 113-121 (1999-01-12)
Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained from homogenates
Lack of effect of catheterization on the pharmacokinetics of (-)-carbovir in rats.
C L Zimmerman et al.
Pharmaceutical research, 13(9), 1417-1418 (1996-09-01)
C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 20(1), 47-51 (1992-01-01)
The recently synthesized carbocyclic 2',3'-didehydro-2',3'-dideoxy-6-deoxy-6-amino-guanosine [(-)6AC] was evaluated as a prodrug for carbovir, carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine [(-)CBV] in seven male Sprague-Dawley rats. A randomized three-way cross-over design was used. Rats were assigned to receive the following treatments: a 20 mg/kg (-)6AC
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Contenu apparenté

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

HPLC de petites molécules

Les petites molécules sont des ions ou des composés d'une masse moléculaire généralement inférieure à 900 daltons. Ces molécules peuvent être séparées efficacement et analysées par HPLC, UHPLC et LC-MS en utilisant essentiellement des particules de silice ou des phases stationnaires monolithiques présentant un large éventail de chimies de colonnes (modifications) différentes.

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