Z4250
Zymosan A from Saccharomyces cerevisiae
for inducing inflamatory response
Synonyme(s) :
Yeast Cell Wall
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About This Item
Produits recommandés
Source biologique
Saccharomyces cerevisiae
Forme
powder with small lumps
Technique(s)
flow cytometry: suitable
tissue culture: suitable
Couleur
off-white to light brown
Température de stockage
2-8°C
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Catégories apparentées
Application
- in flow cytometry
- to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)
Zymosan A from Saccharomyces cerevisiae has been used:
- as a positive control to determine the activation of complement cascade
- for respiratory burst (RB) assay
- to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
- a stimulating agent in Krebs-Ringer phosphate (KRP) medium
- to induce thermal hyperalgesia in mice
Actions biochimiques/physiologiques
Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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