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Z103

Sigma-Aldrich

Zolpidem

≥98% (HPLC), solid, benzodiazepine receptor agonist

Synonyme(s) :

N,N,6-Trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide

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About This Item

Formule empirique (notation de Hill):
C19H21N3O
Numéro CAS:
82626-48-0
Poids moléculaire :
307.39
Numéro MDL:
MFCD00153885
Code UNSPSC :
12352200
ID de substance PubChem :
24902172
Nomenclature NACRES :
NA.77

product name

Zolpidem, ≥98% (HPLC), solid

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Contrôle du médicament

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

Couleur

white

Solubilité

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
DMSO: >10 mg/mL
ethanol: 50 mg/mL
methanol: 50 mg/mL
H2O: insoluble
dilute aqueous base: insoluble

Auteur

Sanofi Aventis

Chaîne SMILES 

CC1=CN2C(C=C1)=NC(C3=CC=C(C)C=C3)=C2CC(N(C)C)=O

InChI

1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

Clé InChI

ZAFYATHCZYHLPB-UHFFFAOYSA-N

Informations sur le gène

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRG2(2566)
rat ... Gabra1(29705) , Gabra2(29706) , Gabra5(29707) , Tspo(24230)

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Actions biochimiques/physiologiques

Potent and selective agonist for the benzodiazepine receptor associated with the GABAA receptor; hypnotic.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation markEnvironment
GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H336,H411

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Ji-Yeong Byeon et al.
Archives of pharmacal research, 41(8), 861-866 (2018-08-18)
Zolpidem is indicated for the short-term treatment of insomnia and it is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C19, CYP1A2, and CYP2C9. Therefore, we evaluated the effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of zolpidem
Sara C Mednick et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4494-4504 (2013-03-08)
An important function of sleep is the consolidation of memories, and features of sleep, such as rapid eye movement (REM) or sleep spindles, have been shown to correlate with improvements in discrete memory domains. Because of the methodological difficulties in
Hsin-I Shih et al.
Medicine, 94(17), e809-e809 (2015-05-02)
We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD).A retrospective population-based nested case-control study. Newly diagnosed dementia patients 65 years and older and controls were sampled. A
Eunmi Kim et al.
Forensic science international, 269, 50-55 (2016-11-21)
The southern area of South Korea consists of three parts; Busan, Ulsan and Gyeongsangnam-do. Busan Institute of National Forensic Service (NFS) performed about 50,000 cases throughout the southern area in 2014, occupying over 15% of total cases covered by NFS.
Franck Da-Silva et al.
Journal of pharmaceutical sciences, 107(7), 1957-1972 (2018-03-11)
The objective was to compare, with the same data set, the predictive performance of 3 in vitro assays of hepatic clearance (CL), namely, micropatterned cocultures (also referring to HepatoPac®) and suspension as well as monolayer hepatocytes to define which assay is
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