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Key Documents

WH0000675M1

Sigma-Aldrich

Monoclonal Anti-BRCA2 antibody produced in mouse

clone 3D12, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-FACD, Anti-FAD, Anti-FAD1, Anti-FANCB, Anti-FANCD, Anti-FANCD1, Anti-breast cancer 2, early onset

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About This Item

Numéro MDL:
MFCD01321778
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

3D12, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

Isotype

IgG3κ

Numéro d'accès GenBank

NM_000059

Numéro d'accès UniProt

P51587

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... BRCA2(675)

Description générale

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated gene is located on human chromosome 13q13.1. BRCA2 and BRCA1 colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes.

Immunogène

BRCA2 (NP_000050, 3319 a.a. ~ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Actions biochimiques/physiologiques

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated protein encodes a protein that promotes homologous recombination, which is essential for normal development. Mutations causes tumor formation and cell lethality. Bi-allelic mutations of BRCA2 is associated with Fanconi anemia (FA). BRCA2 alterations can be used as a prognostic marker for pancreatic cancer.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline, pH 7.4

Informations légales

GenBank is a registered trademark of United States Department of Health and Human Services

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
Chen J, et al.
Molecular Cell, 2(3), 317-328 (1998)
Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption
Meyer S, et al.
Cell Death & Disease, 8(6), e2875-e2875 (2017)
Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization
Jonsson G, et al.
Cancer research, 65(17), 7612-7621 (2005)
The role of BRCA2 mutation status as diagnostic, predictive, and prognosis biomarker for pancreatic cancer
Martinez-Useros J and Garcia-Foncillas J
BioMed Research International, 2016, e2875-e2875 (2016)
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
Feng W and Jasin M
Nature Communications, 8(1), 525-525 (2017)

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