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U7508

Sigma-Aldrich

Anti-UVRAG antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-UV radiation resistance-associated gene

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~90 kDa

Espèces réactives

mouse, human

Concentration

~1 mg/mL

Technique(s)

western blot: 2-4 μg/mL using whole extracts of mouse brain and human Hela cells

Numéro d'accès UniProt

Q9P2Y5

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... UVRAG(7405)
mouse ... Uvrag(78610)

Description générale

Ultraviolet irradiation resistance-associated gene (UVRAG) is an important autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.

Immunogène

synthetic peptide corresponding to amino acids 665-678 of human UVRAG, conjugated to KLH. The corresponding sequence is identical in mouse.

Application

Anti-UVRAG antibody has been used in:
  • immunoblotting
  • western blotting
  • immunofluorescence

Anti-UVRAG antibody produced in rabbit has been used:
  • in western blotting
  • in immunofluorescence

Actions biochimiques/physiologiques

Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.

Description de la cible

UVRAG activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a prot

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila
Lee G, et al.
Developmental Biology, 356(2), 588-597 (2011)
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Knaevelsrud H, et al.
Autophagy, 6(7), 863-870 (2010)
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
He S
Nature Communications (2015)
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.
Yin X
EMBO Reports, 12, 727-734 (2011)
Chonsaeng Kim et al.
Journal of virology, 88(1), 434-443 (2013-10-25)
Echovirus 7 enters polarized Caco-2 intestinal epithelial cells by a clathrin-mediated endocytic process and then moves through the endosomal system before releasing its genome into the cytoplasm. We examined the possible role in virus entry of core components of the
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