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U0881

Sigma-Aldrich

Uric acid

BioXtra, ≥99% (HPLC)

Synonyme(s) :

2,6,8-Trihydroxypurine

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About This Item

Formule empirique (notation de Hill):
C5H4N4O3
Numéro CAS:
69-93-2
Poids moléculaire :
168.11
Numéro Beilstein :
156158
Numéro CE :
200-720-7
Numéro MDL:
MFCD00005712
Code UNSPSC :
12352005
ID de substance PubChem :
24900620
Nomenclature NACRES :
NA.55

Source biologique

animal (seabird feces (guano))

Gamme de produits

BioXtra

Pureté

≥99% (HPLC)

Forme

powder

Impuretés

≤0.005% Phosphorus (P)

Résidus de calcination

≤0.1%

Pf

>300 °C (lit.)

Solubilité

1 M NaOH: soluble 50 mg/mL, clear, faintly yellow

Traces de cations

Al: ≤0.005%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.05%
Mg: ≤0.001%
NH4+: ≤0.05%
Na: ≤0.1%
Pb: ≤0.001%
Zn: ≤0.0005%

Chaîne SMILES 

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

Clé InChI

LEHOTFFKMJEONL-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Uric acid is the terminal product of purine degradation in humans. It is formed from the action of xanthine oxidase upon xanthine. Elevated levels of uric acid may clinically be manifested as gout. In species other than humans, uric acid can be further metabolized. In mammals other than primates, uric acid is converted to allantoin. In teleost fish, allantoin is further converted to allantoate, which is hydrolyzed to urea and glyoxylate. Uric acid may also be used in the biosynthesis of purines. It has been studied as a scavenger of biological free radicals like peroxynitrite. High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods for uric acid have been published. Uric acid promotes monocyte chemoattractant protein-1 (MCP-1) expression in vascular smooth muscle cells.

Application

Uric acid has been used:
  • to prepare monosodium urate (MSU) crystals to study its effect on nuclear localization leucine-rich-repeat protein 1 (NLRP1) gene expression
  • as a reductant to test its protective potential against met-myoglobin formation
  • to prepare MSU to study its use as specific ligand of Clec12a.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Oxonic acid potassium salt 97%

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156124

Oxonic acid potassium salt

Xanthine ≥99.5% (HPLC), purified by recrystallization

Sigma-Aldrich

X0626

Xanthine

Allantoin ≥98.0% (N)

Sigma-Aldrich

05670

Allantoin

Hypoxanthine ≥99.0%

Sigma-Aldrich

H9377

Hypoxanthine

Xanthine ≥99%

Sigma-Aldrich

X7375

Xanthine

Creatinine hydrochloride ≥97%

Sigma-Aldrich

C6257

Creatinine hydrochloride

John Kanellis et al.
Hypertension (Dallas, Tex. : 1979), 41(6), 1287-1293 (2003-05-14)
Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC) proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory effects on VSMCs. Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte
Waleed Al Abdulmonem et al.
Protein and peptide letters, 28(3), 282-289 (2020-09-23)
Myoglobin is an oxygen binding protein and its dysfunction has been associated with the pathology of several human disorders. This study was undertaken to investigation the role of hydrogen peroxide (H2O2) in the formation of met-myoglobin and the protective potential
Francesca Viazzi et al.
Pediatrics, 132(1), e93-e99 (2013-06-19)
Hyperuricemia has been shown to be a strong correlate of hypertension in children. However, the complex interaction between serum uric acid (UA), systemic blood pressure (BP), and possibly confounding factors has been elucidated only in part. We evaluated office BP
S F Seys et al.
Allergy, 70(2), 187-194 (2014-11-02)
Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite
Tom M Palmer et al.
BMJ (Clinical research ed.), 347, f4262-f4262 (2013-07-23)
To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as
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Articles

Uric Acid in Cell Culture

Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.

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