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T8761

Sigma-Aldrich

Tyloxapol

nonionic surfactant

Synonyme(s) :

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

Numéro CAS:
25301-02-4
Numéro MDL:
MFCD00149002
Code UNSPSC :
12161900
ID de substance PubChem :
24900557
Nomenclature NACRES :
NA.25

CMC

0.018 mM

Température de transition

cloud point 94.3 °C

Chaîne SMILES 

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

Clé InChI

GWJOFBXSBDVUMH-UHFFFAOYSA-N

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Description générale

A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Application

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction. Tyloxapol is used in the development of non-ionic surfactant-based liposomes (niosomes) for use in drug delivery systems. Tyloxapol may be used to study its mechanism of protecting macrophages from endotoxins. Tyloxapol may be used to study is potential cell toxicitiy.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

235.4 °F - closed cup

Point d'éclair (°C)

113 °C - closed cup

Équipement de protection individuelle

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Zhenhua Wu et al.
International journal of molecular sciences, 19(8) (2018-08-08)
Endoplasmic reticulum (ER) stress is highly associated with liver steatosis. B-cell receptor-associated protein 31 (BAP31) has been reported to be involved in ER homeostasis, and plays key roles in hepatic lipid metabolism in high-fat diet-induced obese mice. However, whether BAP31
Jung-hua Steven Kuo et al.
Pharmaceutical research, 23(7), 1509-1516 (2006-06-17)
Tyloxapol, a viscous polymer of the alkyl aryl polyether alcohol type, is classified as a nonionic surfactant and is widely used in biomedical applications. Although tyloxapol has been reported to be cytotoxic in various cell lines, there is no published
Jung-Hua Steven Kuo et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 208-215 (2008-03-14)
Tyloxapol is reported to prevent macrophages from reacting to endotoxin. However, the intracellular responses that tyloxapol induces in macrophages are still not fully explored. Hence, the objective of this study was to evaluate the intracellular events in macrophages treated with
Koneni V Sashidhara et al.
European journal of medicinal chemistry, 57, 302-310 (2012-10-20)
A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition
Tatyana A Korolenko et al.
The Journal of pharmacy and pharmacology, 63(6), 833-839 (2011-05-19)
The effects of atorvastatin on the atherogenic and anti-atherogenic lipoprotein-cholesterol (C-LP) and lipoprotein-triglyceride (TG-LP) fractions and subfractions at the early stage of murine acute hyperlipidaemia, and its pleiotropic anti-inflammatory effects via the activity of matrix metalloproteinases (MMPs) were studied. Atorvastatin
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