T6704

Tandospirone

≥98% (HPLC)

• Synonyme(s) : (1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt, SM 3997
• Formule empirique (notation de Hill): C₂₁H₂₉N₅O₂
• Numéro CAS: 87760-53-0
• Poids moléculaire : 383.49
• Code UNSPSC : 51111800
• ID de substance PubChem : 329826853
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Conditions de stockage: protect from light
• Solubilité: DMSO: 38 mg/mL
• Auteur: Dainippon Sumitomo
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCN4CCN(CC4)c5ncccn5
• InChI: 1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-
• Clé InChI: CEIJFEGBUDEYSX-FZDBZEDMSA-N

Description

Actions biochimiques/physiologiques

Tandospirone is a partial agonist at 5HT_1A receptors. It significantly reduces haloperidol-induced bradykinesia in a dose-dependent manner. The potency of tandospirone is equal to that of buspirone and approximate half that of diazepam. The potency of tandospirone as a dopamine antagonistic is less than 1/4 that of buspirone.

Caractéristiques et avantages

This compound was developed by Dainippon Sumitomo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable