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T3165

Sigma-Aldrich

7-Methoxy-4-(trifluoromethyl)coumarin

≥99% (TLC)

Synonyme(s) :

Methyl 4-(trifluoromethyl)umbelliferyl ether

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About This Item

Formule empirique (notation de Hill):
C11H7F3O3
Numéro CAS:
575-04-2
Poids moléculaire :
244.17
Numéro Beilstein :
225039
Numéro MDL:
MFCD00132980
Code UNSPSC :
12352204
ID de substance PubChem :
24900113
Nomenclature NACRES :
NA.32

Pureté

≥99% (TLC)

Forme

powder

Solubilité

acetone: 50 mg/mL, clear, colorless to faintly yellow

Fluorescence

λex 333 nm; λem 416 nm in methanol

Chaîne SMILES 

COc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C11H7F3O3/c1-16-6-2-3-7-8(11(12,13)14)5-10(15)17-9(7)4-6/h2-5H,1H3

Clé InChI

HAZHUELNIGDYQH-UHFFFAOYSA-N

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Application

7-Methoxy-4-(trifluoromethyl)coumarin has been used as a substrate in cytochrome P450 2E1 (CYP2E1) activity assay and aromatase assay.

Actions biochimiques/physiologiques

The enzymatic action of cytochrome P450 2E1 (CYP2E1) on 7-methoxy-4-(trifluoromethyl)coumarin results in a fluorescent product 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) that can be measured at 409/530 nm.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Carlo Matera et al.
European journal of pharmacology, 820, 265-273 (2017-12-25)
(±)-3-Methoxy-1-oxa-2,7-diaza-7,10-ethanospiro[4.5]dec-2-ene sesquifumarate (±)-1 was previously characterized as the most selective agonist at α7 neuronal nicotinic acetylcholine receptors in a series of spirocyclic quinuclidinyl-Δ
Gaku Okamatsu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 47(2), 93-102 (2016-03-10)
1. Little is known about drug metabolism in carnivores. Although the domestic cat (Felis catus) is an obligate carnivore and is the most common companion animal, usage and dosage of many drugs are determined according to information obtained from humans and
Vamshi K Manda et al.
Xenobiotica; the fate of foreign compounds in biological systems, 46(2), 117-125 (2015-08-08)
1. Aegle marmelos (bael) is a popular tree in India and other Southeast Asian countries. The fruit is usually consumed as dried, fresh or juice, and is reported to have a high nutritional value and many perceived health benefits. Despite its
Thomas Piper et al.
Drug testing and analysis, 13(5), 916-928 (2020-12-08)
The steroid profile, that is, the urinary concentrations and concentration ratios of selected steroids, is used in sports drug testing to detect the misuse of endogenous steroids such as testosterone. Since several years, not only population-based thresholds are applied but
Yuka Ono et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(6), 627-635 (2018-06-01)
1. Compared to information for herbivores and omnivores, knowledge on xenobiotic metabolism in carnivores is limited. The cytochrome P450 2C (CYP2C) subfamily is recognized as one of the most important CYP groups in human and dog. We identified and characterized
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