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T103

Sigma-Aldrich

Trifluperidol hydrochloride

Synonyme(s) :

4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m tolyl)piperidino]butyrophenone hydrochloride, R 2498, Triperidol

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About This Item

Formule empirique (notation de Hill):
C22H23F4NO2 · HCl
Numéro CAS:
2062-77-3
Poids moléculaire :
445.88
Numéro CE :
218-170-1
Numéro MDL:
MFCD00055195
Code UNSPSC :
12352200
ID de substance PubChem :
24277941
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Niveau de qualité

100

Forme

solid

Conditions de stockage

desiccated

Couleur

white to off-white

Solubilité

DMSO: ≥20 mg/mL
H2O: soluble
ethanol: moderately soluble

Chaîne SMILES 

Cl.OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3cccc(c3)C(F)(F)F

InChI

1S/C22H23F4NO2.ClH/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26;/h1,3-4,6-9,15,29H,2,5,10-14H2;1H

Clé InChI

VYGQXRZAHIZHQV-UHFFFAOYSA-N

Informations sur le gène

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Application

The interaction of Trifluperidol hydrochloride with NMDA receptors was studied in rat brain buffy coat membranes.

Actions biochimiques/physiologiques

Trifluperidol is a dopamine receptor antagonist with antipsychotic effects used in the treatment of schizophrenia. This neuroleptic penetrates the brain and also affects the glial cells leading to increased release of proinflammatory cytokines. It also alters the metabolism of carbohydrates and amino acids in the brain cortex.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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L L Coughenour et al.
The Journal of pharmacology and experimental therapeutics, 296(1), 150-159 (2000-12-21)
The use of trifluoroperazine in a well washed rat brain membrane preparation revealed [(3)H]ifenprodil binding to a single high affinity state with the pharmacology of N-methyl-D-aspartate (NMDA) receptors containing NR2B subunits. Inhibition of [(3)H]ifenprodil binding in the presence of trifluoroperazine
H Michalek et al.
The Biochemical journal, 110(2), 237-241 (1968-11-01)
1. The effect of triperidol on the metabolism of glucose, pyruvate, glutamate, aspartate and glycine was studied with rat brain-cortex slices, U-(14)C-labelled substrates and a quantitative radiochromatographic technique. 2. Triperidol at a concentration of 0.2mm decreased the oxygen uptake and
J Kowalski et al.
Polish journal of pharmacology, 56(5), 563-570 (2004-12-14)
Neuroleptics penetrate into the brain, where they act not only on neurons but probably also on glial cells. In the available literature, there are no reports on the effect of neuroleptics on cytokine release in glia cultures. The aim of
K Herrick-Davis et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 226-232 (2000-09-19)
Clozapine is the prototype atypical antipsychotic drug, producing little or no extrapyramidal side effects, while improving negative symptoms of psychosis. Clozapine's high affinity for serotonin receptors has been hypothesized to confer the unique antipsychotic properties of this drug. Recently, we
Lisa Burry et al.
The Cochrane database of systematic reviews, 6, CD005594-CD005594 (2018-06-20)
Guidelines suggest limited and cautious use of antipsychotics for treatment of delirium where nonpharmacological interventions have failed and symptoms remain distressing or dangerous, or both. It is unclear how well these recommendations are supported by current evidence. Our primary objective

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