SRP8055

Tim-3 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• Synonyme(s) : HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIM3, TIMD3
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in CHO cells
• Pureté: ≥98% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: monomer 48 kDa by calculation
• Conditionnement: pkg of 100 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Impuretés: <0.06 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: Q8TDQ0
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... HAVCR2(84868)

Description

Description générale

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

Forme physique

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Autres remarques

The extracellular domain of human Tim-3 (aa 22-200) is fused to the N-terminus of the Fc region of human IgG1.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable