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Key Documents

SRP8039

Sigma-Aldrich

Irisin

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Synonyme(s) :

CD121a, Fibronectin type III domain-containing protein 5 (cleaved), Fibronectin type III repeat-containing protein 2 (cleaved)

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About This Item

Numéro CAS:
1465928-51-1
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Produit recombinant

expressed in CHO cells

Étiquette/Marqueur

FLAG® tagged

Pureté

>95% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~26 kDa

Conditionnement

pkg of 10 μg

Impuretés

<0.1 EU/μg endotoxin, tested

Numéro d'accès UniProt

Q8NAU1

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... FNDC5(252995)

Description générale

Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1.

Actions biochimiques/physiologiques

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.

Forme physique

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.

Informations légales

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance.
Moreno-Navarrete JM, et al.
The Journal of Clinical Endocrinology and Metabolism, 98, E769-E778 (2013)
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
Huh JY, et al.
Metabolism, Clinical and Experimental, 61, 1725-1725 (2012)
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
Staiger H, et al.
PLoS ONE, 8, e61903-e61903 (2013)

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