SRP8036

IL-36β mouse

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized

• Synonyme(s) : Interleukin-1 family member 8, Interleukin-36β, Sentrin-specific protease 2
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• product name: IL-36β mouse, recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)
• Source biologique: mouse
• Produit recombinant: expressed in E. coli
• Conjugué: untagged
• Pureté: >95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~17 kDa
• Conditionnement: pkg of 10 μg
• Impuretés: <0.01 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: Q9D6Z6
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: mouse ... Il36b(69677)

Description

Description générale

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Forme physique

Lyophilized from PBS and 0.5% trehalose.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

IL-36beta (mouse) (aa 31-183) is untagged.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable