Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

SRP8015

Sigma-Aldrich

Progranulin mouse

>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized

Synonyme(s) :

GPx-1, PEPI, Proepithelin

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

product name

Progranulin mouse, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)

Source biologique

mouse

Produit recombinant

expressed in HEK 293 cells

Conjugué

untagged

Pureté

>95% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~65 kDa by SDS-PAGE

Conditionnement

pkg of 10 μg

Impuretés

<0.1 EU/μg endotoxin, tested

Couleur

white

Numéro d'accès UniProt

P28798

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

mouse ... Grn(14824)

Description générale

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Forme physique

Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique