SRP2125

RXRα, ligand binding domain, (200-462), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonyme(s) : FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720, NR2B1
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Pureté: ≥80% (SDS-PAGE)
• Forme: frozen liquid
• Poids mol.: ~56.5 kDa
• Conditionnement: pkg of 10 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Concentration: 350 μg/mL
• Couleur: clear colorless
• Numéro d'accès NCBI: NM_002957
• Numéro d'accès UniProt: P19793
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... RXRA(6256)

Description

Actions biochimiques/physiologiques

Retinoid X receptor (RXR) serves as a promiscuous heterodimerization partner for many nuclear receptors through the identity box, a 40-amino acid subregion within the ligand binding domain (LBD). RXR partners include thyroid hormone receptors (TRs), retinoic acid receptors (RARs), peroxisome proliferator-activated receptor, several constitutive active orphan nuclear receptors (e.g. nuclear growth factor I-B), oxysterol receptors, and constitutive androstane receptors. RXRs also form homodimers to mediate the effects of 9-cis-retinoic acid (9-cRA). Depending on these protein-protein interactions, RXR-containing complexes have distinct ligand-dependent and constitutive functions. The LBD is functionally complex and mediates ligand binding, receptor homo- and heterodimerization, repression of transcription in the absence of ligand, and ligand-dependent activation of transcription. Hormone binding to the structurally conserved LBD of the RXR triggers a conformational change that principally affects the conserved C-terminal transactivation helix H12 involved in transcriptional activation. Coactivators directly recruited by liganded receptors include members of the steroid receptor coactivator/p160 family such as SRC-1, transcriptional intermediary factor 2/glucocorticoid receptor interacting protein 1, and RAC3/activator of thyroid and retinoic acid receptors/amplified in breast cancer 1.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable