SRP2084

VHL human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

• Synonyme(s) : HRCA1, RCA1, VHL1
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: human
• Produit recombinant: expressed in insect cells
• Pureté: ≥70% (SDS-PAGE)
• Forme: frozen liquid
• Poids mol.: ~26 kDa
• Conditionnement: pkg of 5 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Concentration: 650 μg/mL
• Couleur: clear colorless
• Numéro d'accès NCBI: NM_000551
• Numéro d'accès UniProt: P40337
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... VHL(7428)

Description

Actions biochimiques/physiologiques

von Hippel-Lindau (VHL) disease is a hereditary cancer with a predilection for the central nervous system and retina. The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxia-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1a. VHL protein binds to elongin B, elongin C, and Cul2 to form a stable complex that targets hypoxia inducible factors (HIFs) for degradation and transcriptional regulation. In addition, VHL protein has also been shown to interact with specific protein kinase C isoforms, histone deacetylases and HIF-1 inhibitor (HIF-1).

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable