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Key Documents

SRP0352

Sigma-Aldrich

TRKC active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Synonyme(s) :

NT-3 Receptor, NTKR3, Neurotrophic Tyrosine Kinase Receptor, type 3

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About This Item

Numéro CAS:
2122170-03-8
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in baculovirus infected Sf9 cells

Pureté

≥70% (SDS-PAGE)

Forme

aqueous solution

Poids mol.

68 kDa

Conditionnement

pkg of 10 μg

Technique(s)

activity assay: suitable
inhibition assay: suitable

Numéro d'accès NCBI

NM_002530

Numéro d'accès UniProt

Q16288

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... NTRK3(4916)

Description générale

Human TRKC, also known as NTKR3 (Neurotrophic Tyrosine Kinase Receptor, type 3) or NT-3 Receptor, (GenBank Accession No. NM_002530), amino acids 456-825 (end) with N-terminal GST-tag, MW=68kDa, expressed in Sf9 cells via a Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

L Tessarollo et al.
Development (Cambridge, England), 118(2), 463-475 (1993-06-01)
The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily
L M McGregor et al.
Genomics, 22(2), 267-272 (1994-07-15)
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system. We have cloned and sequenced the human trkC cDNA and found that the predicted amino
F Lamballe et al.
Cell, 66(5), 967-979 (1991-09-06)
We report the isolation and molecular characterization of trkC, a new member of the trk family of tyrosine protein kinase genes. trkC is preferentially expressed in the brain. In situ hybridization studies revealed trkC transcripts in the hippocampus, cerebral cortex
Ke Zhang et al.
Stem cell reviews, 10(4), 612-625 (2014-05-03)
In the past decades, mesenchymal stem cells (MSCs) as a promising cell candidate have received the most attention in the treatment of spinal cord injury (SCI). However, due to the low survival rate and low neural differentiation rate, the grafted
Oswald Steward et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(42), 14013-14021 (2014-10-17)
We reported previously the formation of ectopic colonies in widespread areas of the nervous system after transplantation of fetal neural stem cells (NSCs) into spinal cord transection sites. Here, we characterize the incidence, distribution, and cellular composition of the colonies.
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