Accéder au contenu
Merck
Toutes les photos(2)

Key Documents

SRP0330

Sigma-Aldrich

BTK active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Synonyme(s) :

AGMX1, BPK, Bruton agammaglobulinemia tyrosine kinase, PSCTK1

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Numéro CAS:
391968-46-0
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in baculovirus infected Sf9 cells

Pureté

≥80% (SDS-PAGE)

Forme

aqueous solution

Poids mol.

106 kDa

Conditionnement

pkg of 10 μg

Technique(s)

activity assay: suitable
inhibition assay: suitable

Numéro d'accès NCBI

NM_000061

Numéro d'accès UniProt

Q06187

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... BTK(695)

Description générale

Human BTK (GenBank Accession No. NM_000061), full length with N-terminal GST-tag, MW= 106 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M Liljeroos et al.
Cellular signalling, 19(3), 625-633 (2006-10-06)
Lipoteichoic acid (LTA) of Gram-positive bacteria initiates innate immune responses via Toll-like receptor-2 (TLR2), resulting in the activation of intracellular signaling and production of inflammatory cytokines in macrophages. Although Bruton's tyrosine kinase (Btk) is biologically important molecule implicated in immune
Ximena Zottig et al.
The protein journal, 36(6), 478-488 (2017-10-05)
Recent investigations of Aneurinibacillus thermoaerophilus strains have allowed identification of a unique solvent tolerant lipase, distinct from known lipases. This work reports the expression and purification of this lipase (LipAT) and the first characterization of its structure and temperature and
Niklas Feldhahn et al.
The Journal of experimental medicine, 201(11), 1837-1852 (2005-06-09)
Pre-B cells undergo apoptosis unless they are rescued by pre-B cell receptor-dependent survival signals. We previously showed that the BCR-ABL1 kinase that is expressed in pre-B lymphoblastic leukemia bypasses selection for pre-B cell receptor-dependent survival signals. Investigating possible interference of
Miran Rada et al.
Oncotarget, 8(63), 106639-106647 (2018-01-02)
p53 is a tumour suppressor that is activated in response to various types of stress. It is regulated by a complex pattern of over 50 different post-translational modifications, including ubiquitination by the E3 ligase MDM2, which leads to its proteasomal
Sheau-Pey Wang et al.
Rheumatology (Oxford, England), 54(8), 1488-1497 (2015-03-01)
B cells play an important role in the pathogenesis of autoimmune diseases. The role of Bruton's tyrosine kinase (Btk) in cytokine-induced human B cell differentiation and class-switch recombination remains incompletely defined. This study analysed the effect of Btk on human

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique