SRP0327

PADI-2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)

• Synonyme(s) : Peptidyl arginine deiminase, type II
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: human
• Produit recombinant: expressed in baculovirus infected Sf9 cells
• Pureté: ≥60% (SDS-PAGE)
• Forme: aqueous solution
• Poids mol.: 77 kDa
• Conditionnement: pkg of 10 μg
• Numéro d'accès NCBI: NM_007365
• Numéro d'accès UniProt: Q9Y2J8
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... PADI2(11240)

Description

Description générale

Human PADI2, also known as Peptidyl arginine deiminase, type II, (GenBank Accession No. NM_007365), amino acids 1-665 (end) with C-terminal FLAG-tag, MW= 77kDa, expressed in a Baculovirus infected Sf9 cell expression system. Peptidyl arginine deiminase, protein-2 (PADI2) is mapped to human chromosome 1p36. It is expressed in Sertoli cells at the time of testicular development.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. PADI-2 human has been used in in vitro binding assays.

Actions biochimiques/physiologiques

Peptidyl arginine deiminase, protein-2 (PADI2) promotes protein citrullination and represses the multiplication of cells. It helps to transform the amino acid arginine in a protein into amino acid citrulline. PADI2 participates in epigenetic mechanisms. It is linked with rheumatoid arthritis.

Forme physique

Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 3 mMDTT, and 20% Glycerol.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable